BioSocial Health journal 3060-6268 2 2 2025 07 15 Propolis’ Potential for Drug Discovery 91 93 10.34172/bshj.87 EN José Maurício Sforcin https://orcid.org/0000-0003-3466-4895 Journal Article 10.34172/bshj.87 2025 04 04 2025 04 30 Introduction: Propolis has been popularly used for centuries for treating inflammatory diseases and wounds. This review aimed to present a short report on in vitro and in vivo assays, clinical trials using propolis, and the main outcomes obtained. Methods: Recent research (2010-2024) conducted in vitro using different cell types, and in vivo studying laboratory animals was reviewed. Clinical trials using propolis were also analyzed. Results: Data revealed the significant antimicrobial, anti-inflammatory, and antitumor effects of propolis in isolation or combination with medicines, indicating its efficiency and usefulness. Conclusion: Propolis’ pharmacological activities demonstrate its potential role as an adjuvant or alternative to conventional drugs, alone or in combination with drugs commonly used to treat several diseases. Since propolis composition may change according to phytogeographic conditions, a standardization of research on propolis is imperative.